MUC16 and familial pancreatic carcinoma: Overexpression of C1GalT in pancreatic cancer reduced the appearance of the TF precursor structure Tn on integrin-αV and -α5 whereas knockdown of C1GalT1 in T3M4 PDAC cells increased Tn occurrence on mucin protein MUC16 and increased phosphorylation of integrin-α4 [31,40].