As C1GalT1 is a glycosyltransferase that controls the biosynthesis of a core glycan structure in cells, the reported glycosylation changes and impact on these cell membrane glycoproteins likely represent only the tip of an iceberg and many other cellular glycoproteins are most likely also affected by C1GalT1 overexpression in cancer. Here, C1GALT1 is linked to cancer.