C1GalT1 overexpression in hepatocellular cancer HCC36 cells by transfection increased TF occurrence on integrin-β1, whereas knockdown of C1GalT1 by shRNA in HA22T hepatocellular cancer cells suppressed the TF expression on integrin-β1 [35]. The gene discussed is C1GALT1; the disease is hepatocellular carcinoma.