C1GALT1 and familial pancreatic carcinoma: It should be mentioned that, although mice orthotopically injected with C1GalT knockdown pancreatic cancer HPAC and HPAF-II cells grew smaller tumors than those injected with control cells [31], c1galt1 knockout mice created by crossing c1galt1 floxed (C1galt1loxp/loxp) mice with KrasG12D/+; Trp53R172H/+; Pdx1-Cre (KPC) mice showed lower survival than KPC mice [40].