C1GALT1 and malignant colon neoplasm: Transfection of human colon cancer HCT116 and SW480 cells with C1GalT1 reduced the binding of Tn-binding lectin VVA to FGFR2 while knockdown C1GalT1 increased VVA binding to FGFR2 (indications of increased and reduced FGFR2 O-glycosylation, respectively) in the cells [24].