It has been reported that the contents of EVs collected from serum, such as miR-200, lipocalin-2 [86], miR-505-5p [91], ubiquitin C-terminal hydrolase-L1 (UCHL1) [88], cell-free DNA [82,83], and proteins [195,196,197,198,199], are useful for the diagnosis of lung cancer. The gene discussed is UCHL1; the disease is lung cancer.