Furthermore, several mesenchymal tumors carry driver translocations (for instance, FUS-CHOP t(12; 16)(q13; p11) in myxoid liposarcoma [38] or EWS/FLI1 t(11; 22)(q24; q12) and the likes in Ewing’s sarcoma [39]) and are characterized by a relatively simple karyotype. This evidence concerns the gene EWSR1 and Ewing sarcoma.