Unlike its tumor suppressor role in breast and ovarian cancer [4,38,145,146], SALL2 is part of the four-core neurodevelopmental transcription factors (including POU3F2, SOX2, and OLIG2) in GBM, which are sufficient to fully reprogram differentiated glioblastoma cells (DGCs) into stem-like tumor propagating cells (TPCs). Here, SOX2 is linked to neoplasm.