However, in both in vivo (xenografted mouse study) and in vitro studies (on ER-positive MCF-7 cells), Mauro et al. found that a low level of adiponectin (5 μg/mL), corresponding to the plasma level in women with obesity, increased cell and tumor growth, and a higher level of adiponectin (30 μg/mL), corresponding to the plasma level in normal-weight women, had no significant effect on cell and tumor growth [178,179,180]. This evidence concerns the gene ADIPOQ and obesity due to melanocortin 4 receptor deficiency.