CD274 and neoplasm: The secretion of IL-10 is considered pro-tumorigenic, but also the secretion of matrix metalloproteinases (MMPs), vascular endothelial growth factor A (VEGF-A), chemokine (C-C motif) ligand 18 (CCL-18), programmed death-ligand 1 (PD-L1), and transforming growth factor beta (TGF-β) have shown tumor-promoting features [8,69].