These mitochondrial genes included MT-CO1, MT-CO2, MT-CO3, MT-ATP6 and 8, and MT-ND2,3,4,5, and 6 (Figure 6D, left), which are critical for energy production and cancer cell survival and likely important for thwarting of therapy effectiveness observed in these FOXM1 inhibitor-resistant cells. This evidence concerns the gene FOXM1 and cancer.