More recently, YB1 was found to play key roles in the regulation of tumor development, progression and metastasis, as well as drug resistance in several cancers, including the ones generated in the breast [17,24,26,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45]. This evidence concerns the gene YBX1 and neoplasm.