In addition, queuine tRNA-ribosyltransferase (QTRT1), the enzyme that catalyzes the hypermodification of queuosine using 7-aminomethyl-7-carbaguanine, is highly expressed in lung adenocarcinoma (LUAD) [32], and has been identified as a risk factor for the progression of LUAD [32]. Here, QTRT1 is linked to lung adenocarcinoma.