The overall secretome analysis revealed signatures characterizing hypoxic lung cancer EV-educated primary NK and NK92 cells involved inflammation and angiogenesis (VEGF, CXCL1, CXCL2 and IL-8/CXCL8), inflammatory chemokines (IL-6 and CCL2), tissue remodeling (MMP-1 and MMP-7) and immuno-suppressive factors (S100A8) at the protein level (Figure 3d–g). This evidence concerns the gene S100A8 and lung cancer.