Whilst the role of PLK1 in DMGs within an in vivo setting is yet to be functionally determined, the non-inflammatory tumour microenvironment within this setting would support the absence of macrophage toll-like receptor 4 (TLR-4) engagement, required for LPS-induced signalling [258] within the macrophage cell model used above [257]. The gene discussed is PLK1; the disease is neoplasm.