Highly expressed PLK1 promotes TNFα-stimulated gene 6 (TSG6) signalling and enhances an invasive phenotype in lung cancer cells [255], with TSG6 activation preventing the macrophage expression of proinflammatory M1 markers such as iNOS, IL-6, TNFα and IL-1β while increasing the expression of anti-inflammatory M2 markers such as CD206, IL-4 and IL-10 [256]. This evidence concerns the gene TNFAIP6 and lung carcinoma.