They found that animals with GBM tumours containing specific phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations (C420R and H1047R) exhibited more seizures, while transcriptomic analysis revealed higher expression levels of genes involved in the formation of synapses [297]. The gene discussed is PIK3CA; the disease is glioblastoma.