From these data, as well as those generated from a previous preliminary study [248], comprehensive analysis found that GBM TAMs also express comparatively lower levels of the M2 markers CD163, TGFβ and IL-10 compared to control macrophage populations specifically polarised to an M2 phenotype despite demonstrating increased activation of the STAT3 signalling pathway, a characteristic indicative of an M2 phenotype [247]. Here, TGFB1 is linked to glioblastoma.