These studies highlight that, although not routinely examined within the setting of DMGs, targeting pathways commonly expressed in tumours and infiltrating TAMs such as mTOR and STAT3 signalling or polyamine synthesis and transport may provide an additive effect that disrupts the cross-talk between immune and malignant cells, effectively reducing immunosuppression and promoting tumour sequestration and removal [262]. This evidence concerns the gene STAT3 and neoplasm.