Studies showed certain small molecules, such as NPI-0052, a proteasome inhibitor, and DETA/NO, a Nom donor, and immunomodulating agents (e.g., anti-CD20 and anti-CD8) have the ability to sensitize cancer cell lines to chemotherapy related apoptosis and TNF-related apoptosis through inhibition of the NF-kB and Snail signaling and induction of RKIP [12,85,136,200,201,202,203,204]. The gene discussed is SNAI1; the disease is cancer.