SMAD4 and juvenile polyposis syndrome: Other hereditary syndromes associated with gastric cancer include Lynch syndrome (the cumulative risk for stomach cancer is highest for MLH1 and MSH2 carriers: 7% and 8%) [16], and hereditary gastrointestinal polyposes, familial adenomatous polyposis, FAP (mutation in Adenomatous Polyposis Coli gene) [17,18,19], Peutz–Jeghers syndrome (mutation in STK 11 gene) [20], juvenile polyposis (mutations in SMAD4 and BMPR1A genes) [21] and Li–Fraumeni syndrome (mutation in p53 gene) [22].