It starts JAK2/STAT3 for production of NOS as IL-6 and STAT1 pathways and is the only cytokine among the complex panorama of mediators, which is incapable of mediating information between leukocytes instead of transmitting information from leukocytes to the rest of the cellular world (such as fibroblasts and tumor cells). This evidence concerns the gene JAK2 and neoplasm.