This agent is a pyrrole-imidazole polyamide indole-seco-CBI conjugate) which recognizes and alkylates the adenine residues on the template strand at codon 12 (GTT and GAT), exon 2 of mutated KRAS, producing strand cleavage which in turn decreases the proliferation rate of the CRC cell harboring G12D/G12 V mutation [44]. Here, KRAS is linked to colorectal carcinoma.