Zimmermann et al., developed Deltarasin, a small molecule inhibitor of PDEδ and demonstrated in the pre-clinical study that PDEδ inhibition by Deltarasin not only blocked the oncogenic RAS signaling but suppressed both in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells with highly prevalent oncogenic KRAS mutant genes [58]. The gene discussed is PDE6D; the disease is pancreatic ductal adenocarcinoma.