Early phase clinical trials are thus exploring metformin and anti-PD-1 combination therapy in advanced non-small-cell lung cancer (NCT03048500) [261], colorectal cancer (NCT03800602) [262] and metastatic head and neck cancer (NCT04414540, NCT03618654) [263,264] and may suggest whether this approach has a future role in OC management. This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.