SIRPA and hematologic disorder: Several solid tumor types and hematological malignancies overexpress CD47, enabling immune escape from components of the innate immune system such as macrophages, dendritic cells, and natural killer (NK) cells via binding signal regulatory protein alpha (SIRPα); these effects lead to the disruption of direct tumor killing, and the resultant impairment in antigen presentation and T cell infiltration [9].