This was followed by investigations on a wide variety of solid and hematological cancer types, including head and neck small-cell carcinoma (HNSCC), breast cancer, acute myeloid leukemia (AML), non-Hodgkin’s lymphoma (NHL), myeloma demonstrating differential overexpression of CD47 between cancer cells and matched normal cells [9,20,21,24,26,27,28,29]. The gene discussed is CD47; the disease is cancer.