Additionally, a miR-199a-5p/HIF1α/STAT3 positive feedback loop promotes resistance of NSCLC cells to the anti-angiogenic drug bevacizumab [52], while miR-206 decreases angiogenesis in A549 xenografts by inhibiting the STAT3/HIF1α/VEGF pathway [45]. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.