BCL2 and non-small cell lung carcinoma: Treatment of mice with GQ-ODN blocked the growth of NSCLC xenografts and significantly downregulated the expression of anti-apoptotic genes (e.g., BCL-2, BCL-xL, MCL-1), cell-cycle regulators (e.g., Cyclin D1 and c-MYC), and pro-angiogenic factors (e.g., VEGF) [250,251].