PTGS2 and cancer: This study also demonstrated significant overexpression of genes involved in the mitochondrial oxidative phosphorylation respiratory chain, such as cyclooxygenase-2 (COX2), a gene that encodes for cyclooxygenase, which plays a vital role in inflammation and has been shown to be overexpressed in various cancers as it also plays a role in cell proliferation, neovascularization, and tumor metastasis [93,94,95,96].