Interestingly, NHERF1/EBP50 is a strong diagnostic marker for ependymoma in general, is an organizer of polarity structures such as ependymal cilia, and as further discussed in the ST-YAP1 section, has a domain PDZ-2 that binds to both β-catenin and YAP1 [51]. Here, YAP1 is linked to ependymoma.