Of importance, this study demonstrated tumor expression of p53, MDM2, HIF-1α, topoisomerase II-b, p-STAT3 and nucleolin while also showing growth suppression of SE cells ex vivo utilizing a topoisomerase inhibitor (WP744) and the p-STAT3/HIF-1α inhibitors (WP1066 and WP1193). This evidence concerns the gene MDM2 and neoplasm.