In addition, the promoter regions of specific genes in metastatic castration-resistant prostate cancer (GSTP1, RASSF1A, and SLFN11) and in diffuse large B-cell lymphoma (CDKN2A and CDKN2B) are found to be methylated in both evDNA and primary tumor tissue or CTCs, respectively [183,184]. This evidence concerns the gene RASSF1 and neoplasm.