RASSF1 and melanoma: Similarly, Mori and colleagues assessed the prognostic and predictive significance of detecting specific methylated genes in the serum of melanoma patients undergoing biochemotherapy [78]: they found that hypermethylation of RASSF1A was the best predictor of response and OS, thus corroborating previous evidence found in other malignancies of resistance to cisplatin and tamoxifen associated with RASSF1A hypermethylation [186,187].