The breast cancer cell lines are attracted through chemokines CXCL16 and CXCL12 by fibroblasts that are associated with BCBM and therefore, blocking receptor-ligand interaction of CXCR6-CXCL16/CXCR4-CXCL12, which may be preventive therapy for BCBM [51]. Here, CXCL12 is linked to breast carcinoma.