Last not least, endothelial Jagged1 also strengthened tumour dysplasia via two different effects: (1) a pro-angiogenic effect, enhancing tumour vascular density, maturation, and perfusion, and (2) an angiocrine outcome, likely through stimulation of NOTCH3/Hey1 and its effects on tumour cell proliferation. The gene discussed is NOTCH3; the disease is neoplasm.