CASP8 and head and neck squamous cell carcinoma: Interestingly, HNSCC lesions that harbour mutations in any of the central players (NOTCH1-4, Notch ligands, and modulators AJUBA, EP300, and FBXW7) show different mutation spectra, for example are enriched in mutations of caspase 8 (CASP8) and FAT4 (Figure 1).