On the whole, the number of interactions was higher in AD + CRC vs. C than in the rest of comparisons and all genes carried SNPs that interact with SNPs of other genes, with the exception of CEL and LIPE genes in cholesterol esters metabolism pathway; and SMPD1 gene in Glycerophospholipid, Sphingolipid metabolism, Glycosylphosphatidylinositol(GPI)-anchor biosynthesis, as well as PLA2G3 and PLA2G12B genes but only in CRC vs. C (Figure 1). Here, SMPD1 is linked to Alzheimer disease.