In addition, there is a clear dominance of hyperactivating JAK-STAT gene mutations across the γδ T-cell lymphoma/leukaemia entities, particularly in STAT5B, STAT3, JAK3 and JAK1. Notably, STAT5 and STAT3 also have clear roles in regulating the epigenetic and chromatin landscape [264]. Here, STAT3 is linked to leukemia.