Tumors enriched in the carcinoma-associated fibroblasts involved in TME can secrete hepatocyte growth factor (HGF, ligand for c-Met receptor), and C-X-C motif chemokine 12 (CXCL12, THE ligand for chemokine receptor CXCR4) [110]. The gene discussed is CXCL12; the disease is carcinoma.