For example, the K1 protein increases cell survival by activating the anti-apoptotic pathway PI3K-AKT whereas the v-GPCR contributes to angiogenesis by stimulating the secretion of pro-inflammatory and pro-angiogenic factors, such as VEGF, IL-6 and -8, leading to tumor progression in a paracrine fashion [22,110,187,188,189,190]. This evidence concerns the gene AKT1 and neoplasm.