Overall, in CRC, two major subpopulations of CAFs have been identified through single-cell RNA sequencing: CAF-A (which express ECM remodeling-associated genes, including MMP2, DCN, and COL1A2) and CAF-B (myofibroblast-like that express ACTA2, TAGLN, and PDGFA) [160]. Here, MMP2 is linked to colorectal carcinoma.