Furthermore, Khatib et al. [39,40] showed that CRC circulating cells trigger the release of proinflammatory TNF-α and IL-1β from KCs, thereby upregulating the expression of E-selectin and other adhesion molecules on liver sinusoidal endothelial cells and enhancing liver metastases [39,40]. The gene discussed is TNF; the disease is colorectal carcinoma.