A second recent study using subcutaneous UM tumor xenografts of Gα11Q209L and GαqQ209L UM cells, established in NOD-scid-gamma (NSG) mice, showed that FR inhibited the growth of UM tumors at 0.1 and 0.3 mg/kg, but had no effect on the growth of B-Raf mutant melanoma tumors [121]. This evidence concerns the gene BRAF and neoplasm.