The upregulation of glycolytic intermediates and membrane transporters, such as glucose transferase (GLUT1), hexokinase 1 (HK1), hexokinase 2 (HK2), Phosphofructokinase 1 (PFK1), Phosphofructokinase 2 (PFK2), enolase (ENO), Lactate dehydrogenase A (LDHA), and Monocarboxylate transporters (MCTs) has been highlighted in a few studies in thyroid tumors [80,81]. Here, PFKFB3 is linked to thyroid tumor.