BRAF and thyroid cancer: Nevertheless, thyroid cancer of follicular cell origin encompasses several tumor types by the mutually exclusive driver mutations such as BRAF V600E-mutated tumors (60%), non-V600E BRAF mutations including K601E, RAS-mutated tumors (15%), and mutations or fusions of other receptor tyrosine kinases (12%) such as RET, NTRK and ALK [8].