A dual-purpose theragnostic NP platform composed of near-infrared (NIR) fluorescent polymers has been studied in preclinical thyroid cancer models: (i) siRNA delivery to effectively silence oncogene V-Raf murine sarcoma viral oncogene homolog B (BRAF) in tumor tissue, (ii) tumor accumulation tracking by tumor imaging in thyroid cancer in an in vivo model [77]. Here, BRAF is linked to neoplasm.