However, the lymphocyte count may not well reflect the radiation killing of immune cells in blood as well as the potential anti-tumor immunity, because lymphocytes can be replenished from the spleen and bone marrow, and there are many subpopulations, such as B cells, T cells, CD8, CD4, CD4 helper, CD4 regulator, NK cells, memory cells, as well as proliferating and non-proliferating cells for each subset in the lymphocytes. Here, CD8A is linked to neoplasm.