Mutations in Dnamt3a or loss of Dnamt3a synergize with other alterations such as Kras (G12D/+) [123], FLT3-ITD [22,23], Npm1cA/+ [134], Bcor−/− [135] and IDH2 neomorphic mutations [133] to develop AML in mice (Table 2; Supplementary Figure S3). Here, FLT3 is linked to acute myeloid leukemia.