For example, 4EGI-1 inhibits the formation of the eIF4E–eIF4G complex in breast cancer stem cells [168] and induces apoptosis in malignant pleural mesothelioma [169]; presumably, 4EGI-1 also inhibits the nuclear functions of eIF4E, but this remains to be tested. Here, EIF4E is linked to malignant pleural mesothelioma.