PPL and cervical intraepithelial neoplasia: Focusing first on the three 16E6E7 HFKs (HFK 1, 2, and 3) as models of cervical dysplasia with an active HR HPV infection, there were similar and reproducible expression patterns between these cell lines and in silico analyses of premalignant tissues for five of the ten LASSO-identified genes (CEBPD, KRT16, SLPI, RPS29, and PPL) (Figure 4A).