FLT3-ITD+ AML cells display hyperactivation of a number of kinase pathways, including tyrosine kinases such as AXL, KIT, SRC-family, ERBB, JAK and FLT3 kinases and also serine/threonine kinases, such as PIM, CDK4/6, or CDK7/8/9. Here, CDK4 is linked to acute myeloid leukemia.