However, as only two out of 1039 CRCs (0.2%) showed a complete loss of both SATB2 and CDX2, and the majority of SATB2 negative CRCs showed a strong and diffuse expression of CDX2 (and vice versa), a combined panel of both markers appears to be able to identify the overwhelming majority of colorectal cancers and is probably the most expedient approach for routine diagnostic settings. The gene discussed is SATB2; the disease is colorectal cancer.