(2) Loss of SATB2 is of high prognostic relevance in uni- and multivariate analyses (including UICC stage) in the overall cohort, but shows no independent prognostic value in the overall cohort when the main histomorphological parameters of CRC (tumour budding, WHO grade, CRC subtypes) are added to the multivariate analyses. This evidence concerns the gene SATB2 and neoplasm.