In this study, we investigated the expression of Special AT-rich sequence-binding protein 2 (SATB2) in one thousand and thirty-nine resected CRCs, correlated the results with histomorphologic parameters (CRC subtypes, tumour budding activity, WHO grade) [17], expression of CDX2 [18] as well as clinicopathological parameters (pTNM/UICC staging, microsatellite status, localisation) and analysed the prognostic relevance of SATB2 in the overall cohort and in specific subcohorts. This evidence concerns the gene CDX2 and colorectal carcinoma.