SATB2 and carcinoma: In our cohort of more than one thousand tumours, SATB2 low/absent CRCs were significantly associated with higher UICC stages and massively enriched in tumours with high-risk histomorphological features such as high tumour budding (Bd3) or poorly differentiated carcinomas according to the WHO grade, which is in line with the functional studies postulating the tumour suppressive properties of SATB2 [12,27,28].