CDX2 and cancer: Special AT-rich sequence-binding protein 2 (SATB2), a transcription factor interacting with nuclear matrix attachment regions which is highly expressed in the non-neoplastic colorectal mucosa [3,4], attracted increasing scientific notice for the identification of the colorectal origin of cancers of unknown primary and of CRC metastases [5,6,7,8,9,10], delineating SATB2 as a valid addition to CDX2, which is still the most established immunohistochemical marker associated with colorectal differentiation [5,11].