Interestingly, although SATB2 expression retained its statistical significance in multivariate analyses when UICC stage, resection status, MSI-status, age and gender were incorporated, this independent prognostic power vanished when we added the most common histomorphological parameters of CRC, tumour budding, WHO grade and the different CRC subtypes to our multivariate analyses. The gene discussed is SATB2; the disease is neoplasm.