ATXII was next evaluated for antiproliferative and cytotoxic activities in a larger panel of six ES cell lines and 12 non-ES cell lines (four different pediatric solid tumor cell lines; two ovarian cancer cell lines, including SK-OV-3-MDR-1-6/6 cells that expresses P-glycoprotein; and six triple-negative breast cancer cell lines). Here, ABCB1 is linked to triple-negative breast carcinoma.