PIK3CA and cancer: Interestingly, the differential engineering of isogenic human induced pluripotent stem cells with the heterozygous or homozygous knocking of PIK3CA H1047R, led to different cellular behavior: wt-like in the heterozygous state, cancer-like (with transcriptional remodeling, loss of typical epithelial morphology, decreased differentiation, up-regulation of stemness markers) in the homozygous one.