However, elimination of the stimulatory effect of MCM on Pyk2 and FAK phosphorylation in response to treatment with cytokine/chemokine receptor inhibitors, together with significant autocrine expression of IL-8, SDF-1α, PDGFα, and PDGFβ by glioma cells (Figure S2a), support an essential role for all identified microglial-derived factors (IL-6, EGF, IL-8, PDGFα, and PDGFβ) in the activation of these kinases. This evidence concerns the gene PTK2B and central nervous system cancer.