Inhibitors of PDGFRβ, EGFR, or SDF-1αR (DMPQ, gefitinib, and burixafor, respectively) significantly reduced the stimulatory effect of MCM in all cell lines, confirming the key role of microglia-derived PDGFβ, EGF, and SDF-1α in glioma cell migration (Figure 4b,d,f). The gene discussed is CXCL12; the disease is central nervous system cancer.