XPO1 is located on chromosome arm 2p, a region frequently associated with somatic copy number changes in cancer (e.g., gastric cancer, CLL, lymphomas, neuroblastoma, and rhabdomyosarcoma), and a region that includes putative proto-oncogenes N-MYC, REL, and BCL11A [7,59,60,61,62]. Here, XPO1 is linked to B-cell chronic lymphocytic leukemia.