XPO1 and childhood malignant neoplasm: Current approaches apply in silico modeling to identify and validate XPO1 cargos (http://prodata.swmed.edu/LRNes, accessed on 30 June 2021), many of which function in signaling pathways and cellular regulation, with implications for understanding the pathogenesis of childhood cancer and the effect of pharmacologic inhibition of XPO1 (Table 1).