Notably, GBM samples from non-responsive patients were enriched for PTEN mutations and characterized by high levels of infiltrating and resident innate immune cells, including macrophages, microglia, and neutrophils, all of which were likely involved in establishing an immunosuppressive microenvironment and thus hindering the tumor infiltration of cytotoxic T cells. The gene discussed is PTEN; the disease is glioblastoma.