In melanoma and non-small-cell lung cancer, it was possible to identify the coexistence of different subsets of TILs: not only proliferative and tumor-reactive CD8+ TILs but also a subset of dysfunctional CD8+ T cells that express and secrete CXCL13, leading to B cell recruitment and the formation of tertiary lymphoid structures at tumor sites; these tertiary lymphoid structures are considered to be a good prognostic factor in some solid cancers [63,64,65]. This evidence concerns the gene CD8A and melanoma.