Meng et al. found that miR-21 maintained MDSCs accumulation in the tumor microenvironment and promoted the immunosuppressive ability of MDSCs in Lewis lung cancer-bearing mice by downregulating RUNX1and upregulating YAP, providing the rationale for future studies that will incorporate targeting of miR-21 in MDSCs [59]. Here, YAP1 is linked to neoplasm.