The other 25 subjects (13 males and 12 females, 100% Caucasian, mean age 51.5 ± 14.5 years, mean body mass index (BMI), 26 ± 4.8 kg/m2) with a diagnosis of FH (21 heterozygotes for the LDL receptor mutation, 1 double heterozygote for 2 different mutations of the LDL receptor and 3 subjects wild-type genetics) met the criteria and were enrolled in the study. The gene discussed is LDLR; the disease is familial hyperaldosteronism.