TP53 and B-cell chronic lymphocytic leukemia: In fact, Blume et al. demonstrated, for the first time, the association of lncRNAs and the p53 pathway in CLL and lymphoma by inducing a p53-dependent DNA damage response, which resulted in increased expression of two lncRNAs, NEAT1 and lincRNA-p21, regulating apoptosis or cell-cycle arrest and DNA repair [74].