In addition, PC patients who did not develop pulmonary fibrosis-like changes (moderate without fibrosis, purple dots, and severe without fibrosis, light blue dots) had higher levels of IFN-β than those who had fibrosis-like changes (moderate with fibrosis, pink dots, and severe with fibrosis, blue dots) (Figure 3B). Here, IFNB1 is linked to pachyonychia congenita.