In conclusion, in the attempt to reveal blood biomarkers to predict PC patients undergoing pulmonary fibrosis-like changes, we believe that IL-1α and TGF-β compared to IFN-β could be of great relevance to avoid the molecular pro-fibrotic pattern typical of lung fibrosis, avoiding morbidity and mortality rates typical of lung fibrotic patients. The gene discussed is IFNB1; the disease is pachyonychia congenita.