Patients who had moderate grade of COVID-19 showed a tendency to have higher levels of circulating IFN-β than those who had severe COVID-19 (media ± SEM: 308.2 ± 39 vs. 264 ± 51.1 pg/mL), although no statistical difference was observed between the two groups (Figure 3A, pink vs. blue dots). This evidence concerns the gene IFNB1 and COVID-19.