Administration of IL-22 protects mice from alcohol-induced liver injury and fatty liver, as evidenced by reduced lipid peroxidation and restored glutathione (GSH) levels, by STAT3-dependent activation of antioxidant, antiapoptotic and antimicrobial genes, and by restoring the balance of reactive oxygen species (ROS) and inhibiting TNF-α-mediated hepatocyte apoptosis [21,56,57]. Here, STAT3 is linked to fatty liver disease.