TNF and steatosis: Th17/22 cells then release cytokines, including IL-6, IL-17, IL-22, tumor necrosis factor-α (TNF-α), TGF-β and C-C motif chemokine ligand 20 (CCL20), in mouse models of NASH and in patients with steatosis, which further promote tissue inflammation and recruitment of leucocytes [28,31,32].