A recent meta-analysis, based on 14 clinical trials, evaluating the impact of supervised exercise interventions on obesity and hepatic functions in a cohort of 1231 obese youths aged between 7 and 18 (including 821 in the exercise group vs. 410 in the control group) demonstrated a significant reduction in visceral, subcutaneous and intrahepatic fat, as well as GGT activity (but no change in AST and ALT). This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.