Moreover, long-term lifestyle changes, evaluated in 39/108 children (24 months), improve liver histology characterized by biomarkers (i.e., ALT, AST, GGT, lipid profile and HOMA-IR index) and by specific NASH liver hallmarks (i.e., steatosis, lobular inflammation, hepatocyte ballooning) [68]. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatohepatitis.