Unfortunately, the exact mechanism for angiogenesis remains controversial; despite studies reporting that IL-8 induces VEGF expression via CXCR2 in a murine model [116], Kido et al. presents a contrary view, instead reporting no correlation between IL-8 and VEGF levels in GC tumour sections (n = 56) and elevated levels of IL-8 but normal VEGF amongst human GC mucosa compared to control [117]. The gene discussed is CXCR2; the disease is gastric cancer.