ANGPTL4 and obesity due to melanocortin 4 receptor deficiency: Recent studies revealed that the genetic ablation of Angptl4 in liver or adipose tissue, as well as targeted pharmacological inhibition of ANGPTL4 in hepatocytes significantly reduced circulating TG and cholesterol levels in mice, protecting them against diet-induced obesity, glucose intolerance, liver steatosis, and atherogenesis [124,132].