ANGPTL4 and Insulin resistance: In line with these findings, there have been conflicting observations regarding the levels of circulating ANGPTL4 in humans, with several studies reporting that ANGPTL4 plasma levels were elevated in patients with type 2 diabetes and obese non-diabetic subjects [108,127,128,129,130], while the concentration of ANGPTL4 was lower in another cohort of type 2 diabetes patients and showed an inverse correlation with blood glucose levels and the insulin resistance index [39].