Given the therapeutic potential of ANGPTL4 in metabolic disorders, a number of studies have sought to validate the functional role of ANGPTL4 in energy metabolism using preclinical animal models, with global ANGPTL4 depletion via neutralizing monoclonal antibodies or germline Angptl4 knockout mice and monkeys exhibiting severe metabolic abnormalities under high-fat diet (HFD) feeding [124,125,126]. This evidence concerns the gene ANGPTL4 and Other metabolic disease.