LECT2 and metabolic dysfunction-associated steatotic liver disease: Consistently, recent studies have also demonstrated less M1-type macrophages, as well as a lower M1/M2 ratio in the livers of LECT2-deficient mice, in close association with reduced hepatic inflammation (Figure 2) [66], implicating that increased LECT2 levels may be an early manifestation of NAFLD progression.