Hepatic ANGPTL8 expression is upregulated in response to a number of nutritional stress conditions, including fasting/refeeding, hyperglycemia, hyperlipidemia, and endoplasmic reticulum stress, many of which are also well-established risk factors for NAFLD progression [44,48,150,151]. The gene discussed is ANGPTL8; the disease is metabolic dysfunction-associated steatotic liver disease.