Chrysin was found to be involved in alleviating PD pathology as an anti-inflammatory and anti-oxidant agent, together with modifying S100B, BDNF, nerve growth factor (NGF) and glial cell line-derived neurotrophic factor levels [251], Nrf2, which reduces NO, activates myocyte enhancer factor 2D, a critical transcription factor involved in dopaminergic survival. The gene discussed is NGF; the disease is Parkinson disease.