In this study, Δ9-THCA was found to significantly induce mitochondrial mass levels when compared to rosiglitazone, but not Δ9-THC, and upregulated PGC-1α, a PPARγ interacting protein that plays an important role in mitochondrial biogenesis and could be a potential target in HD. The gene discussed is PPARG; the disease is Huntington disease.