HMOX1 and Seizure: Other compounds such as curcumin have also been found to modulate lipid peroxidation, HO-1 levels, suppression of malondialdehyde (MDA) levels, increasing glutathione and CAT and Nrf2 activities to produce neuroprotective or anti-ageing effects in different models of NDDs [262], capsaicin decreased brain MDA whereas increased GSH and paraoxonase-1 activity in pentylene-tetrazole-induced Seizures [263], piperamide was found to inhibit NF-κB translocation [264] and activated the Nrf2/HO-1 pathway to induce anti-inflammation in different neuroinflammatory disease models [265]