NOS3 and hypertrophy: In contrast to eNOS−/− mice, echocardiography revealed signs of hypertrophy in L-NAME-treated animals by means of a significantly increased inner-ventricular septum thickness (Figure 1A,C) and left-ventricular posterior wall thickness (Figure 1E,G), alongside a significantly decreased left-ventricular inner-diameter (Figure 1B,D) and stroke volume (Figure 1M,O) and a trend toward decreased left ventricular ejection volumes during diastole (Figure 1N,P).