Surprisingly, several HLA genes were also identified among the most altered H3K9ac enrichments in T2D, including HLA-A, HLA-B, HLA-C, HLA-DRB1, HLA-DRB5, HLA-DQA1 and HLA-DQB1 (Table S1 and Figure 3). Here, HLA-DRB5 is linked to type 2 diabetes mellitus.