TCF7L2 and type 2 diabetes mellitus: This is in line with previous studies where TCF7L2 rs7903146 was identified to be significantly associated with angiographically diagnosed coronary artery disease (CAD) in the presence of T2D [38], and in PBMCs from CAD patients, where TCF7L2 was identified as a key gene to be differentially expressed in CAD patients with T2D [39].