In our study, we identified several genetic loci in HLA that have been associated with T1D to be the most differentially enriched in H3K9ac, e.g., HLA-B, HLA-DQB1, HLA-DRB, HLA-DRB5, and HLA-DQA1. This evidence concerns the gene HLA-DRB5 and type 1 diabetes mellitus.